In Stock. We Have Now Changed The Label Of The Nitro250 Without Changing The Formula! TrueMicronized™ Technology With Up To 10x (1000%) The Absorption Over Standard Resveratrol. Liquid Capsules Use Micronized Resveratrol For High Absorption And Bio-Availability. - With resveratrol particles as small as 1-2 Microns - Using Pharmaceutical Grade 99% Pure Resveratrol. The Polygonum Cuspidatum Extract (Resveratrol) Used Is A Pure Trans-Resveratrol Ingredient. RevGenetics Resveratrol Has Been Used In Human Clinical Trials With Positive Results. Our resveratrol was tested by Biomol in 2008, and shown to activate Sirt1 (1).
Liquid Micron Delivery System, in Nitrogen Gas Capsule. Each capsule contains 250mg Trans-Resveratrol. The Resveratrol in this product comes from the Polygonum Cuspidatum plant. The Trans-Resveratrol has been micronized, and the particle reduced and emulsified to Sirtris Resveratrol standards to increase effectiveness and absorption by up to 10 fold. One (1) Nitro250 Capsule is powerful enough to be compared with up to 2500 mg of pure resveratrol capsules when it comes to absorption like Sirtris Resveratrol.
We have formulated the liquid capsule strictly for this high absorption, as there is no doubt this is key for any resveratrol benefits and P53 activation. The following mentions research done in animals and in labs. We do not claim our products will act in a similar fashion in regular people. As a dietary supplement company, we only present the information for your consideration.
*The chart compiled from the study from USPTO Document #20060292099. The absorption study made public by Westphal, the CEO of Sirtris, for Sirtris resveratrol. We are only interested in the absorption studies and are not infringing on any patent claims as we only sell an herbal trans-resveratrol extract and not a drug. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Resveratrol Dosage: Because of the estimated increased absorption that we fashioned after Sirtris resveratrol, we recommend only 1 capsule a day. The dose is powerful as it is equivalent to taking up to 10 capsules of regular resveratrol that you would buy anywhere else. The dosage is based on Albert Einsteins College Of Medicine Study Where People Took about 2 grams a day with positive results (Link To Article).
Why provide 250mg of the Sirtris Resveratrol like product? About 70% of the resveratrol dose given orally as a pill is absorbed; nevertheless, oral bioavailability of resveratrol is low because it is rapidly metabolized in intestines and liver into conjugated forms: glucuronate and sulfonate. Only trace amounts (below 5 ng/mL) of unchanged resveratrol could be detected in the blood after 25 mg oral dose. Even when a very large dose of regular resveratrol (2.5 and 5g) was given as uncoated pill, the concentration of resveratrol in blood was only 2.4umol/L. We believe 250mg of Micronized resveratrol with tween 80 will allow greater absorption compared to regular resveratrol and to all of our other micronized resveratrol capsules without tween 80. We fashioned it after the Sirtris resveratrol which shows high absorption.
."High absorption but very low bioavailability of oral resveratrol in humans". Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004). . "Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent". David J. Boocock, et al (2007).
What about the stability of Micronized Resveratrol? Each individual capsule of the Nitro Resveratrol (Nitro250) product, uses a special opaque capsule that is filled with nitrogen gas and protected for long term storage. It does not matter if you take the capsules out from bottles or decide to transfer them to another container, each individual capsule is protected. If long term storage is important, and you want the product to last more than 2-3 years even after opening the bottle, this is the product to purchase.
Are there any cautions I should be aware of? In studies, resveratrol is suggested to be a weak inhibitor of the P4503A4 liver metabolism system, which is of unknown significance for humans. Taking large amounts of resveratrol may increase blood levels of drugs that are usually metabolized by CYP3A4. This simply means that calcium channel blockers, statins, some immunosuppressant drugs, and erectile dysfunction drugs, may have increased blood levels. Please be cautious when taking resveratrol with anticoagulants or antiplatelet drugs. An increase in adenosine availability is involved in resveratrol cardioprotection in rats. It may be possible that an increase in adenosine can increase uric acid temporarily. As a caution, it is not recommended long term for people with a genetic predisposition to Gout. We also advise the following: * Keep out of reach and do not give to children. * Do not exceed the suggested maximum dose unless your doctor recommends it. * If you have a bad reaction to the supplement discontinue use immediately. * When undergoing treatment for any medical condition, are pregnant (or lactating) please inform your physician when using any nutritional supplements.