RevGenetics: MetaQuercetin Pump, Liquid Super Quercetin
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SKU: MQuercetin-Pump-50ml

MetaQuercetin Pump, Liquid Super Quercetin

Availability: In stock

Non-GMO, No Gluten, No Wheat, No Sugar, Dairy Free. Our Guarantee: If Our Quercetin Doesn't Beat Yours, Simply Return It Within 30 Days For A Full Refund Of Your Purchase. The MetaQuercetin Pump Uses The The Most Powerful Liquid Micelle Technology In The World To Increase It's Absorption And Bioavailability. This Product Is Specifically Made For High Absorption. It Is The First RevGenetics Quercetin Product That Provides High Quercetin Bioavailability. We Estimate This Product To Have An 85 Fold Absorption Over Regular Quercetin. This Estimate Makes A 10mg Serving Equivalent To About 850 Mg Of Regular Quercetin.

Quantity:
$60.00

Liquid Micelle Quercetin: If you take exactly 1 serving a day, this product would last you over 260 days*. (However due to the limits of accuracy of the pump when squeezed, a full squeeze of the pump may provide between (0.166 ml and 0.26 ml at a time) and in actuality may last about 180 days or more.

Our Liquid Micelle Technology is currently used with our MetaCurcumen to achieve a up to a 277 fold increase in plasma absorption. We conservatively estimate that the increase in Quercetin absorption is between 85 fold to up to 185 fold using our micelle technology over regular quercetin. Using our estimates with the Micelle technology we estimate that one 10mg serving could equal up to 850 mg of regular quercetin. We believe that a little over 4 servings would be estimated to be equal to 3.5 grams of quercetin.

Quercetin Is Used In Senolytics: In animal testing that uses Quercetin, the amount of 50mg/kg was used to provide senescent cell clearance in rodents. This would be about 3.5 grams of quercetin in a 70kg person. The scientists coined the term "senolytics" for the new class of study. "We view this study as a big, first step toward developing treatments that can be given safely to patients to extend healthspan"^. At this time this has only been tested in rodents, and we cannot know if it will provide the same benefits to humans until clinical trials have been done.

This is considered a high absorption dietary supplement.

*accurate measurement can only be done with a digital scale at this time as the pump is not as accurate as we would like it to be. ^The statements on this web page have not been evaluated by the Food and Drug Administration. This MetaQuercetin supplement is not intended to diagnose, treat, cure or prevent any disease.

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Nicotinamide Mononucleotide NAD+ And Other Study References:

  1. Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo - (Formentini, 2009)
  2. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity - (Cato, 2009)
  3. A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis - (Imai, 2010)
  4. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway - (Zhuo, 2011)
  5. Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice - (Yoshino, 2011)
  6. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity - (Canto, 2012 )
  7. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. - (Zhang, 2016)
  8. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging - (Gomes, Sinclair,2013)
  9. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and repercussion - (Yamamoto, 2014)
  10. NAD+ and sirtuins in aging and disease - (Imai, 2014)
  11. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 - (Khan, 2014)
  12. Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model - (Long, 2015)
  13. NAD+ metabolism and the control of energy homeostasis – a balancing act between mitochondria and the nucleus - (Canto, 2015)
  14. NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy  - (Yang, 2016)
  15. NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair - (Fang, 2016)
  16. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans - (Trammell, 2016)
  17. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice - (Trammell, 2016)
  18. β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats - (Kawamura, 2016)
  19. The first human clinical study for NMN has started in Japan - (Tsubota, 2016)
  20. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death - (Wang, 2016)
  21. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice - (Uddin, 2016)
  22. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice - (Mills, 2016)
  23. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice - (de Picciotto, 2016)
  24. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease - (Yao, 2017)
  25. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model - (Martin, 2017)
  26. Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner - (Guan, 2017)
  27. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway - (Wei, 2017)
  28. Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure - (Zhang, 2017)
  29. Modulating NAD+ metabolism, from bench to bedside - (Auwerx, 2017)
  30. Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale. - (Rodriguez, 2017)
  31. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice - (Williams, 2017)
  32. NAMPT-mediated NAD biosynthesis as the internal timing mechanism: In NAD+ World, time is running in its own way - (Poljsak, 2017)
  33. Effect of “Nicotinamide Mononucleotide” (NMN) on Cardiometabolic Function (NMN) - (Clinical In Process)
  34. The dynamic regulation of NAD metabolism in mitochondria - (Stein, 2012)
  35. Novel NAD+ metabolomic technologies and their applications to Nicotinamide Riboside interventions - (Trammel, 2016)
  36. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans - (Meydayni, 2016)
  37. A high-fat, ketogenic diet induces a unique metabolic state in mice.  - (Kennedy, 2007)
  38. Ketone body metabolism and cardiovascular disease. - (Cotter, 2013)
  39. Ketone bodies as signaling metabolites - (Newman, 2014)
  40. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease - (Youm, 2015)
  41. The effect of the Spanish Ketogenic Mediterranean Diet on nonalcoholic fatty liver disease: a pilot study. - (Guisado, 2011)
  42. β-Hydroxybutyrate: A Signaling Metabolite in starvation response - (Morales, 2016)
  43. Physiological roles of ketone bodies as substrates and signals in mammalian tissues - (Robinson, 1980)
  44. Ketone bodies mimic the life span extending properties of caloric restriction  - (Veech, 2017)
  45. Novel ketone diet enhances physical and cognitive performance - (Murray, 2016)
  46. Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. - (Study)
  47. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes - (Cox, 2013)
  48. Neuroendocrine Factors in the Regulation of Inflammation: Excessive Adiposity and Calorie Restriction - (Fontana, 2009)
  49. Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice - (August, 2017)
  50. A randomized trial of a low-carbohydrate diet for obesity - (Foster, 2003)
  51. β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation - (Bae, 2016)
  52. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.  - (Maalouf, 2009)
  53. AMPK activation protects cells from oxidative stress‐induced senescence via autophagic flux restoration and intracellular NAD + elevation  - (Han, 2016)
  54. Regulation of AMP-activated protein kinase by natural and synthetic activators - (Hardie, 2015)
  55. Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes  - (Strasser, 2016)
  56. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation - (Bai, 2011)
  57. Carbohydrate restriction regulates the adaptive response to fasting - (Klein, 1992)
  58. Interventions to Slow Aging in Humans: Are We Ready? - (longo, 2015)
  59. Extending healthy life span–from yeast to humans - (longo, 2010)
  60. Dietary restriction with and without caloric restriction for healthy aging - (Lee, 2016)
  61. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan - (Longo, 2015)
  62. Diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms - (Longo, 2016)
  63. Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle - (Porter, 2015)
  64. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice  - (Newman, 2017)
  65. The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling - (Mouchiroud, 2013)
  66. NAMPT- mediated NAD(+) biosynthesis is essential for vision in mice - (Lin, 2016)
  67. NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair - (Fang, 2016)
  68. Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease - (Gariani, 2017 )
  69. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle - (Canto, 2010)
  70. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity - (Canto, 2012)
  71. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans - (Trammell, 2016)
  72. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice - (Trammell, 2016)
  73. Dietary leucine stimulates SIRT1 signaling through activation of AMPK - (Hongliang, 2012)
  74. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 - (Khan, 2014)
  75. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway - (Zhuo, 2011)
  76. The effect of different exercise regimens on mitochondrial biogenesis and performance - (Philander, 2014)
  77. Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats - (Aragon’s, 2016)
  78. NAD+ Deficits in Age-Related Diseases and Cancer - (Garrido, 2017)
  79. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation - (Ong, 2013)
  80. Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice - (Chang, 2015)
  81. Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds - (Marin-Aguilar, 2017)
  82. The Effects of Ramadan Fasting on Body Composition, Blood Pressure, Glucose Metabolism, and Markers of Inflammation in NAFLD Patients: An Observational Trial - (Mazidi, 2014)
  83. Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type 2 diabetic and coronary heart disease: A randomized clinical trial. - (Raygan, 2016)
  84. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis - (Nichols, 2008)
  85. Are We All Pre-Diabetic? - (Stokel,2016)
  86. Hepatic NAD+ deficiency as a therapeutic target for non-alcoholic fatty liver disease in aging - (Zhou, 2016)
  87. Effect of exercise intensity on post-exercise oxygen consumption and heart rate recovery - (Mann,2014)
  88. A 45-minute vigorous exercise bout increases metabolic rate for 14 hours - (Knab,2011)
  89. Effects of high-intensity resistance training on untrained older men. II. Muscle fiber characteristics and nuclei-cytoplasmic relationships - (Gerontol, 2000)
  90. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice - (Newman, 2017)
  91. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice - (Roberts, 2017)
  92. NK cells link obesity-induced adipose stress to inflammation and insulin resistance - (Wensveen, 2015)
  93. The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation - (Wensveen, 2015)
  94. The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury - (Totsch, 2017)
  95. Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP - (Shen, 2017)
  96. The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders - (Stafstrom, 2012)
  97. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle - (Fredrick 2016)
  98. Digestion and absorption of NAD by the small intestine of the rat - (Henderson, 1983)
  99. Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet - (Shi, 2017)
  100. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans  - (Brenner, 2004)
  101. Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1 - (Ma, 2017)

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